CloneID: SR-2
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing a BALB/c mouse with the 100 kDa cardiotin subunit.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgM format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: The original antibody is specific for cardiotin. Cardiotin is a mitochondrion-associated protein, which is present in cardiomyocytes and skeletal muscle.
Application Notes (Clone): In immunofluorescence assays on cryostat sections of myocardium, the antibody showed the characteristic cardiotin staining pattern in cardiomyocytes. The antibody was reactive with the 60 kDa and the 100 kDa cardiotin subunits of the SR-enriched fraction of swine heart tissue in western blot analysis (Schaart et al., 1997; PMID: 9042960).
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