Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38

Product Description: Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38 is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated to the linker Mc-VC-PAB and the topoisomerase I inhibitor SN38 (HY-13704). The ADC toxic molecule and linker part are Mc-VC-PAB-SN38 (HY-131057). Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38 can be used in cancer research[1][2].

Applications: Cancer-programmed cell death

Formula: N/A

References: [1]Fetterly GJ, et al. Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data. J Clin Pharmacol. 2013 Oct;53(10):1020-7./[2]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Molecular Weight: N/A

Research Area: Cancer

Target: Antibody-Drug Conjugates (ADCs);CCR;Topoisomerase

• Artikelnummer: MEXHY-171684-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-171684-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK