CloneID: 4.9
Antigen Long Description: The original antibody was generated by immunizing human immunoglobulin generating XENOMOUSE™ mice with human CCR2 antigen.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P41597
Specificity Statement: This antibody specifically binds an epitope located within the 2nd extracellular loop of human CCR2. The human C-C chemokine receptor type 2 is a key functional receptor for CCL2 but can also bind CCL7 and CCL12.
Application Notes (Clone): The binding specificity of this antibody to full length CCR2, and 1St and 2nd loop of CCR2 was determined using ELISA. The binding reactivity of this antibody to the surface bound CCR2 receptors was confirmed with flow cytometry. This antibody can positively inhibit chemotaxis of THP-1 monocytes. The therapeutic effects of this antibody were studied in in vivo mouse models of inflammation, multiple sclerosis and neuropathic pain (US8710191).
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