CloneID: scFv1
Heavy Chain modification: ScFv
Antigen Long Description: The original antibody was isolated from an scFv phage display library generated by immunizing two BALB/c mice intradermally with paraformaldehyde fixed HT1080 cells (human fibrosarcoma cell line).
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted mouse scFv antibody, based on the original mouse scFv format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P15151
Specificity Statement: This antibody binds human CD155 also called the poliovirus receptor (PVR). This protein mediates NK cell adhesion and triggers NK cell function. It also binds two NK cell receptors CD96 and CD226. CD155 is gaining more interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.
Application Notes (Clone): The ability of this antibody to bind HT1080,PC3, KHOS and chang liver cells was determined using flow cytometry. This antibody was also capable of immunoprecipitating a 70 kDa protein from HT1080 cell extract (US20090215175).
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