CloneID: OX-34
Heavy Chain modification: Fc Silent™
Antigen Long Description: OX-34 was prepared by immunizing mice with T blasts prepared inmixed lymphocyte reactions with purified rat T helper cells against irradiated spleen.
Buffer Composition: PBS only.
Chimeric Use Statement: This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P08921
Specificity Statement: OX-34 binds specifically to rat CD2. CD2 is type I membrane protein involved in triggering of T-cells (cytoplasmic domain is involved in signaling function) and is expressed on thymocytes, peripheral T cells, dendritic epidermal T cells, macrophages in the spleen, and NK cells.
Application Notes (Clone): Ox34 blocks CD48 binding to CD2 causing partial block of T cell activation; OX34 can be used to deplete peripheral T cells (used to prevent allograft rejection in vivo).
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