Anti-CD20 (VET309 (CD20-6))

Anti-CD20 [VET309 (CD20-6)], Recombinant, IgG lambda, Rabbit

CloneID: VET309 (CD20-6)

Antigen Long Description: The original antibody was generated by immunizing mice with CHO-DG44 cells expressing canine CD20.

Buffer Composition: PBS only.

Uniprot Accession No.: Q3C2E2

Specificity Statement: This antibody binds canine (dog) CD20 and does not cross react with cat CD20. This protein plays an important role in the regulation of cellular calcium influx necessary for development, differentiation, and activation of B-lymphocytes.

Application Notes (Clone): The binding reactivity of this antibody to recombinant dog CD20 expressed on the surface of CHO cells was determined using flow cytometry. This antibody binds recombinant dog CD20 with a binding affinity of Kd= 63.41 nM. This antibody exhibited a strong staining of B cells in a immunohistochemical staining of lymph node tissues collected from dogs with B-cell lymphoma. The ability of this antibody to alter the proliferation of lymphoma cells was checked using cell assays. This antibody was reported to cause a 27% reduction in proliferation of lymphoma cells (US9616120).

• Artikelnummer: ABAAb03765-23.0-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab03765-23.0-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Dog (Canine)
• Klonalität: Recombinant
• Methode: Flow Cytometry, Immunohistochemistry, Functional Assay
• Isotyp: IgG lambda
• Wirt: Rabbit