CloneID: NMB04
Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with purified His tagged human BAFF protein.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q9Y275
Specificity Statement: This antibody binds human BAFF protein and cross reacts with mouse and cynomolgus monkey BAFF protein. B-cell-activating factor (BAFF/CD257) is a cytokine belonging to the tumour-necrosis factor (TNF) family. This cytokine binds to TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. BAFF is a survival factor for B cells that controls B-cell maturation. It is also involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Application Notes (Clone): This antibody is capable of inhibiting the Blys signaling pathway by binding to Blys to block its binding to the receptor. The blocking activity of this antibody was reported to be better than Belimumab. In vitro, this antibody inhibited Blys-stimulated B cell proliferation and also inhibited Blys-stimulated mouse splenocyte proliferation. The original IgG1 version of this antibody binds BLyS with a very high binding affinity of Kd= 7.38E-10M. This antibody significantly inhibited human BLYS-induced activation and proliferation of splenic B cells in vivo (CN105061596).
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