CloneID: OX-61
Antigen Long Description: OX-61 was prepared by immunizing mice with rat thoracic duct lymphoid cells that were enriched for dendritic cells.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P14740
Specificity Statement: OX-61 binds specifically to DPP4. Evidence: tissue distribution of OX-61 and DPP4 are identical; equal MWTs; OX-61-mediated reduction in DPP4 activity from solubilized liver homogenates. DPP4 is a glycoprotein receptor which acts as a positive regulator of T cell co-activation.
Application Notes (Clone): This antibody can be used for denaturing and non-denaturing WB and developed using peroxidase-conjugated rabbit anti-mouse. It can also be used for IHC of cryostat sections from adult rat liver. Staining is also observed on the brush border of the small intestine and colonic epithelium, T cell areas of lymphoid cells but not B cell follicles
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