CloneID: 13B5B11C8
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with CD38.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P28907
Specificity Statement: The antibody is specific for CD38. CD38 is a single-chain transmembrane type II glycoprotein with a molecular weight of 45kD, including a long carboxyl-terminal extracellular domain (258 amino acids), a transmembrane domain (21 amino acids) and a short amino-terminal Intracellular region (21 amino acids). CD38 is a multifunctional protein with receptor and enzyme-mediated functions, which can act as receptor, adhesion molecule and exonuclease.
Application Notes (Clone): The antibody specifically detected CD38 by Western blot analysis. The antibody 13B5B11C8 and the commercial antibody 38C03 were used to stain B-cell lymphoma and T-cell lymphoma. Results showed the antibody specificity is comparable to the commercial antibody. Further, the sensitivity of the antibody 13B5B11C8 was higher than the commercial antibody. The antibody and the commercially available antibody 38C03 were simultaneously detected on the normal tissue chip, indicating that the specificity of the antibody in normal tissue was equivalent to that of the commercially available antibody (CN113912727A).
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