Anti-CD44v6 (BIWA8)

Anti-CD44v6 [BIWA8], Recombinant, IgG1 kappa, Mouse

CloneID: BIWA8

Antigen Long Description: The antibody is the humanized version of the murine BIWA-1.

Buffer Composition: PBS only.

Uniprot Accession No.: P16070

Specificity Statement: The antibody is specific for CD44v6. CD44v6 is a tumor associated antigen abundantly expressed in head and neck squamous cell carcinomas (HNSCC) and in normal squamous epithelium.

Application Notes (Clone): The antibody is the mutated version of BIWA-4 that was constructed with the aim of improving binding affinity. The binding affinity of the antibody to CD44v6 was measured by surface plasmon resonance. The antibody showed a specificity of tumor localization when administrated together with another anti-CD44v6 antibody to mice in in vivo experiments (Verel et al. 2002; PMID: 11992408). The specificity of the humanized version of the antibody was confirmed by ELISA anlaysis (Kd= 0.84 nM). The antibody had good therapeutic efficacy in in vivo experiments in mice. Mice treated with labelled 186Re-BIWA 8 showed a decreased in the tumor volume (US6972324B2).

• Artikelnummer: ABAAb03794-1.1-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab03794-1.1-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: In Vivo Assay
• Isotyp: IgG1 kappa
• Wirt: Mouse