CloneID: Ab10
Heavy Chain modification: ScFv
Antigen Long Description: The original antibody was generated by immunization of Balb/c and Naval Medical Research Institute (NMRI) mice with CD81 extracellular loop 2 (ECL2) protein.
Origin Pub PMID: 29778602
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted mouse scFv antibody, based on the original mouse scFv format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P60033
Specificity Statement: This antibody is specific for the large extracellular loop of human CD81.
Application Notes (Clone): The scFv version of this antibody is based on an anti-CD81 clone whose binding specificity was determined via FACS that was successfully used in an inhibition assay against HCV (Ji et al., 2015; PMID: 25417967). The exact binding site of this antibody was determined via crystallization (Nelson et al., 2018; PMID: 29778602). The scFv version of this antibody was used successfully in FC (Susa et al., 2020; PMID: 32338599).
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