CloneID: OMVU10
Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with bacterial cell suspension of strain HG459 of Streptococcus sobrinus.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody reacts with the purified cell-wall antigen B of Streptococcus sobrinus, which is an anaerobic, gram-positive, catalase-negative, non-motile bacteria. it also cross reacts with Streptococcus downei. Streptococcus sobrinus is a pathogenic bacteria in humans which enhances the formation of caries within teeth. S. sobrinus is also affiliated with early childhood caries, which are responsible for the majority of dental abscesses and toothaches in children.
Application Notes (Clone): This antibody can be used for the identification of different strains of Streptococcus sorbinus using ELISA and immunofluorescence assay. This antibody was not found to cross react with strains other than S. sobrinus (PMID: 3323224). This antibody was used for the enumeration of Streptococci from dental plaque or saliva with the colony immunoblot technique. This antibody could not directly bind S. sobrinus in dental plaque samples, thus the samples were cultured prior to immunological detection and identification (PMID: 2254421).
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