CloneID: RAB-C211
Heavy Chain modification: His-Tagged
Antigen Long Description: The original antibodywas isoltated from an optimised automated phage display library by panning against specific antigens.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human Fab format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q14839
Specificity Statement: This antibody binds human chromodomain-helicase-DNA-binding protein 4 (CHD4). It is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in the gene that encodes this protein are associated with serous endometrial tumors.
Application Notes (Clone): The binding specificity of this antibody to human CHD4 was confirmed with ELISA. This antibody was also used in the immunofluorescense staining of 6 human cell lines (PMID: 26290498).
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