CloneID: 3E5
Heavy Chain modification: AbFab2™ His-Tagged
Antigen Long Description: A covalent serotype A Glucuronoxylomannan (GXM) -tetanus toxoid conjugate (GXM-TT).
Origin Pub PMID: 23911417
Buffer Composition: PBS only.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original mouse IgG3 format for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: Specifically binds to CNPS.
Application Notes (Clone): This antibody binds to Glucuronoxylomannan (GXM), which is the main constituent of the C. neoformans capsule and modulates the inflammatory response of monocytes. In a later study conducted by Yuan et al. 1998 (PMID: 9488395), it was shown that switching the original murine IgG3 antibody to other IgG subtypes, in particular IgG2A, significantly prolonged animal survival in an infection model.
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