Anti-Crotoxin (CTX-scFv8)

Anti-Crotoxin [CTX-scFv8], Recombinant, IgG1 lambda, Human
Artikelnummer
ABAAb00760-10.0
Verpackungseinheit
200 μg
Hersteller
Absolute Antibody

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CloneID: CTX-scFv8

Antigen Long Description: scFv 8 was constructed from a phage display library using V-genes from 43 non-immunized donors.

Origin Pub PMID: 10736105

Buffer Composition: PBS with 0.02% Proclin 300.

Chimeric Use Statement: This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: P24027

Specificity Statement: scFv binds to crotoxin and recognises epitopes overlapping BI-a (an epitopic region at the interface between the CA and CB subunits of the heterodimer) and BIII (an epitopic region on CB involved in the enzymatic activity of CB) - scFv 8 may be able to caused the two subunits to dissociate and suppress the synergistic activity between them. Crotoxin is a phospholipase A2 neurotoxin and is the main toxic component in venome from Crotalus durissus terrificus rattlesnakes, acting by blocking neuromuscular transmission.

Application Notes (Clone): scFv 8 is able to reduce the myotoxicity induced by crotoxin and is able to neutralize the lethality induced by the toxin. This scFv was also used for (competitive ELISAs).
Mehr Informationen
Artikelnummer ABAAb00760-10.0
Hersteller Absolute Antibody
Hersteller Artikelnummer Ab00760-10.0
Verpackungseinheit 200 μg
Mengeneinheit STK
Reaktivität Various species
Klonalität Recombinant
Methode ELISA, Neutralization
Isotyp IgG1 lambda
Wirt Human
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