English
Anti-Crotoxin (CTX-scFv8)
Anti-Crotoxin [CTX-scFv8], Recombinant, IgG lambda, Rabbit
Artikelnummer
ABAAb00760-23.0-BT
Verpackungseinheit
1 mg
Hersteller
Absolute Antibody
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CloneID: CTX-scFv8
Antigen Long Description: scFv 8 was constructed from a phage display library using V-genes from 43 non-immunized donors.
Origin Pub PMID: 10736105
Buffer Composition: PBS only.
Chimeric Use Statement: This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P24027
Specificity Statement: scFv binds to crotoxin and recognises epitopes overlapping BI-a (an epitopic region at the interface between the CA and CB subunits of the heterodimer) and BIII (an epitopic region on CB involved in the enzymatic activity of CB) - scFv 8 may be able to caused the two subunits to dissociate and suppress the synergistic activity between them. Crotoxin is a phospholipase A2 neurotoxin and is the main toxic component in venome from Crotalus durissus terrificus rattlesnakes, acting by blocking neuromuscular transmission.
Application Notes (Clone): scFv 8 is able to reduce the myotoxicity induced by crotoxin and is able to neutralize the lethality induced by the toxin. This scFv was also used for (competitive ELISAs).
Antigen Long Description: scFv 8 was constructed from a phage display library using V-genes from 43 non-immunized donors.
Origin Pub PMID: 10736105
Buffer Composition: PBS only.
Chimeric Use Statement: This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P24027
Specificity Statement: scFv binds to crotoxin and recognises epitopes overlapping BI-a (an epitopic region at the interface between the CA and CB subunits of the heterodimer) and BIII (an epitopic region on CB involved in the enzymatic activity of CB) - scFv 8 may be able to caused the two subunits to dissociate and suppress the synergistic activity between them. Crotoxin is a phospholipase A2 neurotoxin and is the main toxic component in venome from Crotalus durissus terrificus rattlesnakes, acting by blocking neuromuscular transmission.
Application Notes (Clone): scFv 8 is able to reduce the myotoxicity induced by crotoxin and is able to neutralize the lethality induced by the toxin. This scFv was also used for (competitive ELISAs).
| Artikelnummer | ABAAb00760-23.0-BT |
|---|---|
| Hersteller | Absolute Antibody |
| Hersteller Artikelnummer | Ab00760-23.0-BT |
| Verpackungseinheit | 1 mg |
| Mengeneinheit | STK |
| Reaktivität | Various species |
| Klonalität | Recombinant |
| Methode | ELISA, Neutralization |
| Isotyp | IgG lambda |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
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Gernot Ensinger, M.Sc.
Laurent Haze
