CloneID: Fab-BDF1
Heavy Chain modification: Fc Silent™
Antigen Long Description: Human immobilized DR5.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original human Fab format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q9BY82
Specificity Statement: The antibody binds to human DR5 with nanomolar affinity. The original format of this antibody has an IC50-value of 2 nM.
Application Notes (Clone): The antibody binds to human DR5, a receptor that can be activated by tumor necrosis factor-related ligands and transduces apotposis signals. The antibody occludes the smaller of the two Apo2L/TRAIL binding sites on DR5
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