Anti-DR5 (PRO95780 (Drozitumab))

Anti-DR5 [PRO95780 (Drozitumab)], Recombinant, IgG1 lambda, Human

CloneID: PRO95780 (Drozitumab)

Antigen Long Description: The variable domains of this antibody were derived as scFv from a human antibody phage display library, with biotinylated DR5-Fc used to capture DR5-specific phage. The scFv obtained were subsequently reformatted into full-length antibodies.

Buffer Composition: PBS only.

Uniprot Accession No.: O14763

Specificity Statement: This antibody is specific for human death receptor 5, a proapoptotic receptor widely expressed in adult and fetal tissues, with notably high expression on tumour cells. Activation of DR5 triggers apoptosis in various types of cancer cells, without affecting most normal cell types.

Application Notes (Clone): This antibody binds DR5, triggering DR5 clustering and DISC activation in a range of cancer cells, including colorectal cancer and NSCLC cells (Adams, 2009). Conversely, this antibody showed no effector caspase activation or cell death induction in normal human hepatocytes. In vivo, this antibody has been shown to inhibit tumor xenograft growth in a variety of animal models (Varfolomeev, 2009). This antibody was used in IP, immunoblot, ELISA and IF analysis to precisely characterise its interaction with the DR5 ligand (Adams, 2009).

• Artikelnummer: ABAAb00740-10.0-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab00740-10.0-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: Immunofluorescence, Immunoprecipitation, ELISA, Functional Assay, Immunoblotting
• Isotyp: IgG1 lambda
• Wirt: Human