Anti-DR5 (PRO95780 (Drozitumab))

Anti-DR5 [PRO95780 (Drozitumab)], Recombinant, IgG1 lambda, Human
Artikelnummer
ABAAb00740-10.3
Verpackungseinheit
200 μg
Hersteller
Absolute Antibody

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CloneID: PRO95780 (Drozitumab)

Heavy Chain modification: Fc Silent™

Antigen Long Description: The variable domains of this antibody were derived as scFv from a human antibody phage display library, with biotinylated DR5-Fc used to capture DR5-specific phage. The scFv obtained were subsequently reformatted into full-length antibodies.

Buffer Composition: PBS with 0.02% Proclin 300.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: O14763

Specificity Statement: This antibody is specific for human death receptor 5, a proapoptotic receptor widely expressed in adult and fetal tissues, with notably high expression on tumour cells. Activation of DR5 triggers apoptosis in various types of cancer cells, without affecting most normal cell types.

Application Notes (Clone): This antibody binds DR5, triggering DR5 clustering and DISC activation in a range of cancer cells, including colorectal cancer and NSCLC cells (Adams, 2009). Conversely, this antibody showed no effector caspase activation or cell death induction in normal human hepatocytes. In vivo, this antibody has been shown to inhibit tumor xenograft growth in a variety of animal models (Varfolomeev, 2009). This antibody was used in IP, immunoblot, ELISA and IF analysis to precisely characterise its interaction with the DR5 ligand (Adams, 2009).
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Artikelnummer ABAAb00740-10.3
Hersteller Absolute Antibody
Hersteller Artikelnummer Ab00740-10.3
Verpackungseinheit 200 μg
Mengeneinheit STK
Reaktivität Human
Klonalität Recombinant
Methode Immunofluorescence, Immunoprecipitation, ELISA, Functional Assay, Immunoblotting
Isotyp IgG1 lambda
Wirt Human
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