Anti-E-protein DIII (C-C') (ZV-48)

Anti-E-protein DIII (C-C') [ZV-48], Recombinant, IgM kappa, Human

CloneID: ZV-48

Antigen Long Description: This antibody was generated by infecting mice with 1000 FFU of ZIKV MR-766 followed by a booster at 30d post-infection of ZIKV H/PF/2013, respectively and given a final intravenous boost with live ZIKV DIII (amino acids 299 to 407 of the ZIKV E protein))

Buffer Composition: PBS with 0.02% Proclin 300.

Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2c format, for improved compatibility with existing reagents, assays and techniques.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Specificity Statement: ZV-48 binds to the Zika virus envelope protein at domain III (DIII, C-C’ loop). No cross-reactivity with other tested flaviviruses has been reported.

Application Notes (Clone): The original mouse IgG2c format has been shown to have neutralizing activity and has been used to label ZIKV infected cells (4% PFA fixation, 0.1% saponin permeabilization).

• Artikelnummer: ABAAb00810-15.0
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab00810-15.0
• Verpackungseinheit: 50 μg
• Mengeneinheit: STK
• Reaktivität: Virus
• Klonalität: Recombinant
• Methode: Flow Cytometry, Neutralization, Super-Resolution Microscopy
• Isotyp: IgM kappa
• Wirt: Human