Anti-Factor H binding protein (clone4)

Anti-Factor H binding protein [clone4], Recombinant, IgG kappa, Rabbit

CloneID: clone4

Antigen Long Description: The recombinant fHbp protein of Neisseria meningitidis was used as the antigen for the immunization of BALB/c mice. Anti-fHbp VH/k chain ribosome display libraries was generated and the actual antibody was obtained by panning the scFv library against the recombinant fHbp protein by using a single round of the ribosome display method via a rabbit reticulocyte lysate system.

Buffer Composition: PBS only.

Uniprot Accession No.: E6MV22

Specificity Statement: This antibody binds a surface exposed epitope on N. meningitidis FHbp, a virulence factor critical for surviving of the bacteria in the human host. FHbp protein is a bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH). Neisseria meningitidis is the leading global cause of meningitis and sepsis.

Application Notes (Clone): This antibody exhibited high affinity and specificity in the enzyme-linked immunosorbent assay (ELISA) and the whole bacterial cell enzyme-linked immunosorbent assay (Bact-ELISA). The binding affinity of the scFv version of this antibody for fHbp was reported to be Kd= 7.03 nM (PMID: 29737965).

• Artikelnummer: ABAAb03893-23.0-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab03893-23.0-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Various species
• Klonalität: Recombinant
• Methode: ELISA
• Isotyp: IgG kappa
• Wirt: Rabbit