CloneID: Gipg013
Heavy Chain modification: Fc Silent™
Antigen Long Description: Human GIPr.
Buffer Composition: PBS only.
Chimeric Use Statement: This full-length, chimeric rat antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: Q8TDV5
Specificity Statement: The original has a Ki value of 7 nM and a Kd value of 6.8 nM for human GIPr.
Application Notes (Clone): This antibody binds to GIPr, a GPCR expressed on pancreatic beta-cells, where activation leads to the release of insulin. Endogeonous ligands for the receptor include oleylethanolamide and lysophosphatidylcholine. The antibody acts as a competitive antagonist. In rat islets, the antibody inhibits GIP-induced secretion of insulin by up to 81%.
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