Anti-Glycoprotein H (A13-d6.3)

Anti-Glycoprotein H [A13-d6.3], Recombinant, IgG2b kappa, Mouse
Artikelnummer
ABAAb00772-3.0-BT
Verpackungseinheit
1 mg
Hersteller
Absolute Antibody

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CloneID: A13-d6.3

Antigen Long Description: d6.3 was generated by immunizing mice with PrV.

Buffer Composition: PBS only.

Uniprot Accession No.: A0A142I9U7

Specificity Statement: d6.3 Fab fragment binds to the core fragment of the PrV glycoprotein H (gH) ectodomain (aa 107–639) which is the membrane-proximal end of the protein in the ΔgL-Pass PrV variant of PrV. The antibody contacts residues 332-373 (peripheral helices α6 and α7 of domain III of gH contribute most of the residues that form the epitope recognized by d6.3). PrV is a porcine herpesvirus belonging to the alpha-Herpesvirinae subfamily and is known to cause Aukeszky's disease in pigs. gH is a type I membrane portein and can interact non-covalently with gL via the large gH ectodomain.

Application Notes (Clone): d6.3 neutralizes the ΔgL-Pass PrV variant of PrV and can stain ΔgL-Pass PrV variant but not the wild-type PrV by immunostaining. The epitope of d6.3 is not blocked by the formation of the gH/gL heterodimer. The d6.3Fab fragment (obtained through papain digestion) can be complexed with the core fragment of the PrV glycoprotein H (gH) ectodomain (aa 107–639) for structural studies by crystallography.
Mehr Informationen
Artikelnummer ABAAb00772-3.0-BT
Hersteller Absolute Antibody
Hersteller Artikelnummer Ab00772-3.0-BT
Verpackungseinheit 1 mg
Mengeneinheit STK
Reaktivität Virus
Klonalität Recombinant
Methode Neutralization
Isotyp IgG2b kappa
Wirt Mouse
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