CloneID: AbAb2-GPC1
Antigen Long Description: The original antibody was generated by immunizing mice with human glypican-1.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P35052
Specificity Statement: This antibody binds human glypican-1, which is a cell surface proteoglycan that bears heparan sulfate. This protein is required for skeletal muscle differentiation. Glypican-1 (GPC1) was significantly expressed in serum exosomes of patients with pancreatic cancer and so GPC1 is considered as a tumor marker for pancreatic cancer.
Application Notes (Clone): The binding characterization of this antibody to human glypican-1 was determined using ELISA. This antibody was used as a capture antibody in a double antibody sandwich ELISA for the detection of glypican-1 in exosomes. The detection antibody was an anti-glypican 1 rabbit polyclonal antibody (CN111187350).
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