CloneID: RV-Gn1
Antigen Long Description: The original antibody was generated by immunizing New Zealand White rabbits with the full-length RVFV Gn ectodomain.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P21401
Specificity Statement: The antibody is specific for the Gn protein. The antibody is directed to the membrane-distal domain of RVFV Gn.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis.The antibody was able to able to neutralize RVFV in vitro. A plaque reduction neutralization test (PRNT) demonstrated that the antibody neutralized RVFV with half-maximal inhibitory concentration (IC50) values ranging from 2.1 to 3.0 μg/mL. The antibody protected against RVFV challenge in a murine infection model. The structure of rift valley fever virus Gn in complex with the Fab fragment of the antibody was determined, revealings that the antibody targeted to the membrane-distal head region of RVFV Gn (Allen et al., 2018; PMID: 30590046).
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