Anti-Junin virus GP1 (GD01)

Anti-Junin virus GP1 [GD01], Recombinant, IgG1 kappa, Mouse
Artikelnummer
ABAAb00771-1.1
Verpackungseinheit
200 μg
Hersteller
Absolute Antibody

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CloneID: GD01

Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with inactivated-virus-infected BALB/c suckling mouse brain emulsion.

Buffer Composition: PBS with 0.02% Proclin 300.

Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: P26313

Specificity Statement: This antibody is specific for the GP1 subunit of the JUNV surface envelope glycoprotein GPC.

Application Notes (Clone): The original version of this antibody (mouse IgG2a) successfully bound Junin virus (XJ45 strain) GP1 in an ELISA. This antibody was used for the indirect immunofluorescent staining of Junin virus-infected Vero cells. This antibody reacted with Junin GP1 in immunoprecipitation and western blot. This antibody successfully neutralized the Junin virus in an in vitro assay (Sanchez et al., 1989; PMID: 2471803). The GP1-bound Fab version of this antibody was crystallized, and its structure was determined. This antibody neutralized the active form of JUNV by disrupting the interaction between GP1 and TfR1. A competition assay showed that IgGs from survivors of AHF did not compete with this antibody (Mahmutovic et al., 2015; PMID: 26651946). This antibody exhibited potent neutralization of the Candid #1 JUNV strain in a plaque neutralization assay (Zeitlin et al., 2016; PMID: 27044104).
Mehr Informationen
Artikelnummer ABAAb00771-1.1
Hersteller Absolute Antibody
Hersteller Artikelnummer Ab00771-1.1
Verpackungseinheit 200 μg
Mengeneinheit STK
Reaktivität Virus
Klonalität Recombinant
Methode Immunofluorescence, Immunoprecipitation, Western Blotting, ELISA, Neutralization
Isotyp IgG1 kappa
Wirt Mouse
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