CloneID: 448-D
Heavy Chain modification: Fc Silent™
Origin Pub PMID: 25965315
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P03377
Specificity Statement: The antibody recognises a conformational epitopes of the gp120 envelope protein of HIV-1
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody was able to block the interaction between recombinant CD4 (rCD4) and rgp120. It was also able to achieve 50% neutralization of HTLV-IIIB and MN strains of HIV-1 in a concentration range of 0.5-12.8 micrograms/mL. The binding affinity of the antibody for gp120 in solution was measured, dissociation constants (Kd) equal to 29 nM.
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