CloneID: 559/64-D
Antigen Long Description: The antibody was generated by fusing Ab-producing cells pooled from two separate patients.
Origin Pub PMID: 25965315
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P03377
Specificity Statement: The antibody recognises a conformational epitopes of the gp120 envelope protein of HIV-1.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody was able to block the interaction between recombinant CD4 (rCD4) and rgp120. It was also able to achieve 50% neutralization of HTLV-IIIB and MN strains of HIV-1 in a concentration range of 0.5-12.8 micrograms/mL. The binding affinity of the antibody for gp120 in solution was measured, dissociation constants (Kd) equal to 40 nM.
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