CloneID: A7
Antigen Long Description: A phage immune library generated from a long-term non-progressors with HIV neutralizing antibodies in his plasma. The phage library was screened on recombinant soluble gp140 envelope (Env) proteins and the antibody was isolated.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This full-length chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: The antibody is specific for gp41, and it binds to structural elements of the third variable loop V3.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody showed neutralizing activity against a panel of standardized Tier 1 and Tier 2 HIV-1 pseudo virions on Tzm-bl cells (Trott et al., 2014; PMID:24828352).
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