Anti-HBV pre-S1 protein (MA18/7)

Anti-HBV pre-S1 protein [MA18/7], Recombinant, IgG1 kappa, Mouse

CloneID: MA18/7

Antigen Long Description: The original antibody was generated by immunizing mice with HBsAg subtype ayw.

Buffer Composition: PBS only.

Uniprot Accession No.: Q67886

Specificity Statement: This antibody binds a clearly defined epitope 'DPAF' (amino acids 31-34) of the pre-S1 region of the hepatitis B virus. Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer.

Application Notes (Clone): This antibody can be used for the identification of HBV pre-S2 protein using immunoblot and western blot (PMID: 6492255). The original mouse IgG1 version of this antibody was reported to bind pre-S1 protein of HBV with a binding affinity of Kd= 0.24 nM (PMID: 10509818). Immunoblot analysis revealed that the tetrapeptide Asp-Pro-Ala-Phe (DPAF), located at the position preS(31–34) and conserved in all known HBV genomes, is sufficient to bind MA18/7 antibody (PMID: 1279369). It was reported that MA18/7 inhibits the binding of natural HBV to hepatocyte membranes (PMID: 7964611). This antibody has shown to neutralize infectivity of HBV for primary human hepatocytes, also blocked infection of primary Tupaia belangeri hepatocytes (PMID: 12915565).

• Artikelnummer: ABAAb03888-1.1-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab03888-1.1-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Virus
• Klonalität: Recombinant
• Methode: Western Blotting, ELISA, Neutralization, Functional Assay, Inhibition
• Isotyp: IgG1 kappa
• Wirt: Mouse