CloneID: W3759-cAb1
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by using human IL-33 as an immunogen.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse IgG4 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: O95760
Specificity Statement: This antibody binds an epitope between amino acid residues Ser112-Thr270 of the human IL-33. Interleukin 33 (IL-33). Interleukin 33 (IL-33) is a multifunctional cytokine which is constitutively expressed in structural cells such as smooth muscle cells, fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, epithelial cells, and endothelial cells. It is involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines like IL-4, IL-5 and IL-13. It is also involved in activation of mast cells, basophils, eosinophils and natural killer cells. A study found that IL-33 is a bifunctional protein. On the one hand, IL-33 is localized in the nucleus and acts as a transcription factor; on the other hand, IL-33 is secreted outside the cell and acts as a cytokine by interacting with its receptor ST2.
Application Notes (Clone): This antibody binds human IL-33 with a high binding affinity of 0.776 pM. The binding characterization of this antibody was done using ELISA and SPR (CN111620948).
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