Anti-IL-34 (FAb1.1)

Anti-IL-34 [FAb1.1], Recombinant, IgG1 kappa, Human

CloneID: FAb1.1

Antigen Long Description: The original antibody was generated by panning a Fab library against IL-34.

Buffer Composition: PBS only.

Uniprot Accession No.: Q6ZMJ4

Specificity Statement: The antibody is specific for human and murine IL-34. The antibody recognizes a largely continuous area at the junction of two IL-34 protomers. The epitope overlaps largely with binding epitopes responsible for CSF-1R binding.

Application Notes (Clone): The crystal structure of the Fab fragment of the antibody in complex with human IL-34 was determined. The original antibody was reformatted as an IgG molecules and the binding affinity of both formats measured by BLI experiments (Kd= 17 nM and 120 pM respectively). The antibody blocked the biological activity of IL-34 in human monocyte viability. The antibody neutralized IL-34 in a proliferation assays (Ma et al., 2012; PMID: 22483114).

• Artikelnummer: ABAAb03933-10.0-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab03933-10.0-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Recombinant
• Methode: Blocking, Neutralization
• Isotyp: IgG1 kappa
• Wirt: Human