CloneID: FAb1.1
Antigen Long Description: The original antibody was generated by panning a Fab library against IL-34.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q6ZMJ4
Specificity Statement: The antibody is specific for human and murine IL-34. The antibody recognizes a largely continuous area at the junction of two IL-34 protomers. The epitope overlaps largely with binding epitopes responsible for CSF-1R binding.
Application Notes (Clone): The crystal structure of the Fab fragment of the antibody in complex with human IL-34 was determined. The original antibody was reformatted as an IgG molecules and the binding affinity of both formats measured by BLI experiments (Kd= 17 nM and 120 pM respectively). The antibody blocked the biological activity of IL-34 in human monocyte viability. The antibody neutralized IL-34 in a proliferation assays (Ma et al., 2012; PMID: 22483114).
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