CloneID: 3.3
Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with the protein InlB.
Buffer Composition: PBS only.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Uniprot Accession No.: P0DQD3
Specificity Statement: The antibody recognized epitopes within the leucine-rich repeat (LRR) region (amino acids 73-248) and/ or the inter-repeat (IR) region(amino acids 249-342). It recognizes either an epitope overlapping the LRR and IR regions, or a conformational epitope not recognized by the antibody when one of the two regions is absent.
Application Notes (Clone): This antibody binds to InIB, a surface protein that mediates entry of Listeria monocytogenes into a wide variety of cell types. Binding affinity of the antibody was determined by ELISA and western blotting was used to confirm the specificity of the antibody. In particular, the antibody recognizes the region LRR and IR of INIB, indicating these regions of the protein are responsible for the entry into mammalian cells.
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