CloneID: CR1-10
Antigen Long Description: The original antibody was isolated from the peripheral blood lymphocytes of a human patient who had been immunized with Candid#1 2 years prior to sampling. Candid#1 is a live attenuated JUNV vaccine.
Buffer Composition: PBS only.
Uniprot Accession No.: P26313
Specificity Statement: This antibody binds the GP1 subunit of their envelope glycoprotein of Junin virus (JUNV). This antibody does not bind the TfR1 receptor binding site in GP1. Junin virus also known as Argentinian mammarenavirus is an arenavirus in the Mammarenavirus genus which causes Argentine Haemorrhagic Fever (AHF). Mammarenaviruses sporadically cause zoonotic infections in humans, which may lead to life-threatening viral haemorrhagic fever (VHF) disease. VHFs caused by arenaviruses are acute diseases with considerable mortality rates. Symptoms are fever, malaise, headache, nausea, diarrhea, petechial hemorrhage of the soft tissues, lethargy, and irritability. Members of the Arenaviridae family are enveloped viruses with a bi-partite RNA genome coding for four viral proteins. The virus is spread through the aerosolization of host rodent excreta.
Application Notes (Clone): This antibody is capable of binding Junin virus GP1 and GP1 mutant by ELISA. The Fab version of this antibody binds JUNV GP1 with a binding affinity of Kd=25nM. This antibody shows mild neutralization of JUNV (PMID: 29760382).
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