CloneID: H11F6
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was isolated from a human non-immune scFv phage display library by screening antibodies against a 44-mer polypeptide corresponding to the CTAR1/TES1 site of LMP1 (TES1 polypeptide).
Origin Pub PMID: 14659750
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This full-length reformatted human antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P03230
Specificity Statement: This antibody specifically binds the CTAR1/TES1 (C terminus activation region 1/transformation effector site 1) which comprises the membrane-most proximal 34 amino acids (amino acid residues 196–231) of carboxy-terminal cytoplasmic tail of the oncogenic latent membrane protein 1 of the Epstein-Barr virus (EBV). EBV latent membrane protein 1 (LMP1) is essential to virus-induced B cell immortalization and the downregulation of cell adhesion molecules that increases cell motility. It acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation.
Application Notes (Clone): The binding characterization of this antibody to the TES1 polypeptide of the LMP1 protein of Epstein-Barr virus was done using ELISA. This antibody can selectively block F-LMP1-induced NFkappaB activity that was mediated through the TES1-site and to bind LMP1 protein with high efficiency (PMID: 14659750).
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