Anti-LPS (S20)

Anti-LPS [S20], Recombinant, IgG kappa, Rabbit
Artikelnummer
ABAAb00793-23.0
Verpackungseinheit
200 μg
Hersteller
Absolute Antibody

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CloneID: S20

Antigen Long Description: Ig-inactivated transgenic mice possessing human heavy and light Igs (strain XMG2) were immunized with heat-killed 06ad P. aeruginosa. The supernatants from the derived hybridomas were screened for IgG mAb production against the 06ad high molecular weight LPS O-side-chain using ELISA.

Buffer Composition: PBS with 0.02% Proclin 300.

Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Specificity Statement: S20 binds to the polysaccharide (PS) portion of the lipopolysaccharide O side chain of a common pathogenic serogroup of P. aeruginosa, 06ad. The antibody also binds Fisher Devlin immunotype 1 P. aeruginosa, (considered part of the 06 serogroup) but there is no cross-reactivity with LPSs from other P. aeruginosa serotypes (strains IATS 011, IATS 016, 170003, and PAO1 Holloway). P. aeruginosa is a human pathogen, which poses a serious risk to individuals with weak immune systems. LPS is a serotypic marker present on the surface of the bacterium.

Application Notes (Clone): S20 human MAb is highly opsonic (complement-dependent) for the uptake and killing of live and heat-killed P. aeruginosa by fresh human PMN ( polymorphonuclear leukocytes). BALB/c mice rendered neutropenic challenged with 06ad P. aeruginosa saw 100% protection from mortality. S20 can also be used to detect 06ad LPS by ELISA.
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Artikelnummer ABAAb00793-23.0
Hersteller Absolute Antibody
Hersteller Artikelnummer Ab00793-23.0
Verpackungseinheit 200 μg
Mengeneinheit STK
Reaktivität Various species
Klonalität Recombinant
Methode ELISA, Neutralization
Isotyp IgG kappa
Wirt Rabbit
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