CloneID: cAbHul6
Antigen Long Description: Phage libraries were generated using the mRNA extracted from the lymphocytes of immunized dromedaries. The VHH antibody was isolated by biopanning from the libraries.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P61626
Specificity Statement: The antibody is specificity for human lysozyme. It does not cross react with hen lysozyme.
Application Notes (Clone): The binding affinity of the VHH fragment for human lysozyme was measured by surface plasmon resonance (Kd = 0.7 nM) (Dumoulin et al., 2002; PMID: 11847273). The antibody stabilized an unstable human lysozyme mutant that forms fibrils and amyloids.The crystal structure of the original version of the antibody in complex with human lysozyme was determined (Dumoulin et al., 2003; PMID: 12917687). The original antibody was humanized and the binding affinity for human lysozyme was measured by surface plasmon resonance (Kd = 2.36 nM). The crystal structure of the humanized version of the antibody in complex with human lysozyme was determined (Vincke et al., 2009; PMID: 19010777).
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