CloneID: MQ128
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing BALB/c and MRL/MpJUmmCrj-lpr/lpr mice with Muc17ct_mIgG2aFc fusion protein.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: Q685J3
Specificity Statement: This antibody binds human mucin-17, which is a membrane-bound mucin that provides protection to gut epithelial cells from carcinogenic effects of chronic inflammation. It is also indicated that mucin-17 is highly expressed in gastric cancer specimens and is a compelling target for prognosis of gastric cancer.
Application Notes (Clone): The binding specificity of this antibody for human mucin-17 was determined using ELISA. The binding of this antibody to a pancreatic cancer cell line AsPc1 was evaluated by flow cytometry (US8546546).
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