CloneID: RS2-1G9
Heavy Chain modification: Fc Silent™
Antigen Long Description: The 4-methoxyphenyl amide AHL analog.
Origin Pub PMID: 17400249
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: Binds 3-oxo-C12-HSL with a Kd of 150 nM
Application Notes (Clone): This antibody, originally raised in mice, binds to several homoserine lactones from P. aeruginosa. Homoserine lactones (HSL) are signalling molecules in bacteria used for quorum sensing, required for successful estabilshment of infecion. RS2-1G9 interferes with quorum sensing and was shown to protect murine bone marrow derived macrophages, from the cytotoxic P. aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone (PMID: 18304641).
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