Anti-NCAM-L1 (H2 scFv)

Anti-NCAM-L1 [H2 scFv], Recombinant, IgG2a lambda, Mouse
Artikelnummer
ABAAb00744-2.0-BT
Verpackungseinheit
1 mg
Hersteller
Absolute Antibody

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CloneID: H2 scFv

Antigen Long Description:  single-chain variable fragment antibodies against mouse L1 from a human synthetic phage display library.

Buffer Composition: PBS only.

Chimeric Use Statement: This full-length, chimeric mouse antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: P11627

Specificity Statement: This scFv binds specifically to the fibronectin type III repeats 1–2 of mouse L1 with a KD of around 2μM (determined by ELISA). It does not cross-react with human L1 in ELISAs, Western blots or immunofluorescence staining of cultured neurons. L1 plays important roles in cell adhesion, neuronal migration, neurite outgrowth, fasciculation and pathfinding, neuronal survival, and synaptic plasticity. L1 is not recongised under reducing conditions. L1 is a membrane glycoprotein of the immunoglobulin superfamily. Its interacts with adhesion molecules and proteins of the ECM. L1 also is inolved in the migration of cerebellar granule cells, enhancing neuronal survival and memory.

Application Notes (Clone): This scFv can stimulate neurite outgrowth from cerebellar dorsal, rootganglion and motor neurons and also be used to enhance survival of cerevellar neurons by facilitating the clustering of L1. H2 can also be used for ELISA, WB and IF studies.
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Artikelnummer ABAAb00744-2.0-BT
Hersteller Absolute Antibody
Hersteller Artikelnummer Ab00744-2.0-BT
Verpackungseinheit 1 mg
Mengeneinheit STK
Reaktivität Mouse (Murine)
Klonalität Recombinant
Methode Immunofluorescence, Western Blotting, ELISA
Isotyp IgG2a lambda
Wirt Mouse
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