CloneID: PL7-6
Heavy Chain modification: Fc Silenced
Antigen Long Description: This antibody was raised by immunising BALB/c mice with washed platelets.
Origin Pub PMID: 7520038
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P16109
Specificity Statement: This antibody is specific for human P-selectin, which is expressed by activated platelets.
Application Notes (Clone): This antibody has been used in flow cytometric detection of thrombin-stimulated platelets (Katayama et al, 1992), and a chimeric mouse/human version of this antibody also preferentially reacts with activated platelets (Kurome et al, 1994). This could enable the detection of platelets aggregating at sites of blood vessel injury, or the delivery of clot-dissolving drugs. The specificity of this antibody for CD62 has been confirmed in western blot and ELISA (Katayama et al, 1992), and ELISA analysis based on this antibody has been used to assess P-selectin levels in plasma sample of patients post-angina (Ikeda et al, 1995).
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