CloneID: LD2 sAB
Heavy Chain modification: Fc Silent™
Antigen Long Description: Peptide corresponding to paxillin-LD2 motif (residues 141-156) fused to MBP; peptide sequence: NLSELDRLLLELNAVQHNP.
Buffer Composition: PBS only.
Chimeric Use Statement: This full-length, reformatted mouse antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P49023
Specificity Statement: The antibody binds specifically to the LD-2 motif of human paxillin with a Kd of 24 nM.
Application Notes (Clone): This antibody binds to the LD2-motif of human paxillin, a signal transduction adaptor protein involved in focal adhesion, with binding partners including integrins, Src, FAK or actin complexes. The antibody inhibits complex formation between paxillin and FAK. Paxillin is involved in both inside-out cell signalling and outside-to-inside cell signalling.
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