Anti-PD-L1 (BT613)

Anti-PD-L1 [BT613], Recombinant, IgG1 kappa, Human

CloneID: BT613

Antigen Long Description: The original antibody was generated by immunizing transgenic mice with PD-L1, followed by antibody library construction and phage display-based selection against PD-L1.

Buffer Composition: PBS only.

Uniprot Accession No.: Q9NZQ7

Specificity Statement: The original antibody is specific for PD-L1. The antibody recognises human and mouse PD-L1.

Application Notes (Clone): The binding affinity of the antibody to PD-L1 was measured by surface plasmon resonance. The binding affinity of the antibody was measured on the cell lines with high expression of PD-L1 by FACS. The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody had good activity in blocking the binding of PD-L1 to PD-1 and PD-L1 to B7-1 is shown by ELISA analysis. The antibody could block the binding of PD-1 and PD-L1 at the cellular level in in vitro experiments. The antibody was used for in vivo experiments on colon cancer tumor model. B-hPD-1 mice with human PD-1 and MC38-hPD-L1 colon cancer cells with human PD-L1 were treated with the antibody. Results showed inhibition of tumor volume growth in mice treated with the antibody.

• Artikelnummer: ABAAb03784-10.0-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab03784-10.0-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Recombinant
• Methode: Blocking, Super-Resolution Microscopy, In Vivo Assay, Inhibition
• Isotyp: IgG1 kappa
• Wirt: Human