CloneID: 106.3
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original mouse antibody was generated by immunizing mice with human BNP peptide 5-13 (VQGSGAFGR) conjugated with BSA.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P16860
Specificity Statement: This antibody binds B-type natriuretic peptide (BNP) 5‐13 (VQGSGAFGR). BNP is a naturally secreted cardiac regulatory hormone that influences blood pressure and vascular water retention in human physiology. The plasma BNP concentration is a clinically recognized biomarker for various cardiovascular diseases.
Application Notes (Clone): This antibody can be used for the detection of human BNP using ELISA (PMID: 18606632). This antibody when crosslinked to POROS XL ID resin can also be used in the immunoprecipitation of BNP from plasma samples of patients with chronic heart failure (PMID: 16750161).
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