CloneID: 2G8
Antigen Long Description: The original antibody was generated by panning a fully human Naive combined antibody library against RANKL.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: O14788
Specificity Statement: The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease.
Application Notes (Clone): The affinity of the original format of the antibody was determined by Scatchard analysis; the results showed that the affinity of the antibody reached 3.2X10E-9. The specificity of the Fab version of the antibody was confirmed by ELISA analysis. The Fab fragment had a good neutralizing effect when tested in an antagonistic RANKL neutralization ability test (WO2009105934A1).
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