Anti-RANK-L (2G8)

Anti-RANK-L [2G8], Recombinant, IgG kappa, Rabbit

CloneID: 2G8

Antigen Long Description: The original antibody was generated by panning a fully human Naive combined antibody library against RANKL.

Buffer Composition: PBS only.

Uniprot Accession No.: O14788

Specificity Statement: The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease.

Application Notes (Clone): The affinity of the original format of the antibody was determined by Scatchard analysis; the results showed that the affinity of the antibody reached 3.2X10E-9. The specificity of the Fab version of the antibody was confirmed by ELISA analysis. The Fab fragment had a good neutralizing effect when tested in an antagonistic RANKL neutralization ability test (WO2009105934A1).

• Artikelnummer: ABAAb04141-23.0-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab04141-23.0-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: ELISA, Neutralization
• Isotyp: IgG kappa
• Wirt: Rabbit