CloneID: RNL-4
Antigen Long Description: The original antibody was generated by immunizing a BALB/c mouse with a synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of Reticulon-1C.
Buffer Composition: PBS only.
Uniprot Accession No.: Q16799
Specificity Statement: The antibody is specific for reticulon-1C. It recognizes an epitope located within the first 20 amino acids of Reticulon-1C (NSP-C).
Application Notes (Clone): The specificity of the original format of the antibody for NSP-C was established in an ELISA assay. Immunofluorescence analysis of COS-1 cells, transfected with NSP-C cDNA, showed staining of the endoplasmic reticulum with the antibody. The antibody detected NSP-C by western blot analysis (Senden et al., 1996; PMID: 8900485). This antibody was used for immunohistochemistry for the detection of NSP-C on lung carcinoid, atypical carcinoid of the lung, SCLC and squamous cell carcinoma (Senden et al., 1997; PMID: 9227337).
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