CloneID: cAb-RN05
Antigen Long Description: The original antibody was generated by immunizing a dromedary (Camelus dromedarius) with bovine RNase A. The affinity matured version of this antibody was generated using synthetic combinatorial libraries.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P61823
Specificity Statement: This antibody binds bovine RNase A. RNase A is an endonuclease enzyme that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. It acts on single-stranded and double-stranded RNA.
Application Notes (Clone): This antibody binds bovine RNase with an affinity in the picomolar range. This affinity matured version of VHH antibody cAb-RN05 binds bovine RNase with an affinity of Kd= 180 pM (PMID: 17888451). 5′–3′ cUMP that binds into the active site of RNase A does not compete with cAb-RN05 for binding to RNase A in an ELISA (PMID: 10196124).
Deutsch
English
