CloneID: 1G8
Antigen Long Description: A human antibody library generated from the peripheral blood lymphocytes of human donors. This specific clone was isolated by panning the library against human ROR1 protein.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q01973
Specificity Statement: This antibody binds the human ROR1. ROR1 is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. It is a pseudo kinase that lacks catalytic activity. Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes.
Application Notes (Clone): The original human IgG1 version of this antibody binds human ROR1 protein with a binding affinity of Kd= 4.9 nM. This antibody can be used for the detection of human ROR1 using flow cytometry (CN104817642).
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